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Hajime Nakano Selected Research

Ferrochelatase (Heme Synthetase)

1/2022Novel mutation of the ferrochelatase gene in a Japanese boy with erythropoietic protoporphyria.
4/2020Novel mutation of the ferrochelatase gene in a Japanese family with erythropoietic protoporphyria.
6/2019Erythropoietic Protoporphyria in a Japanese Population.
10/2017Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury.
6/2017Case of late-onset erythropoietic protoporphyria with myelodysplastic syndrome who has homozygous IVS3-48C polymorphism in the ferrochelatase gene.
12/2006Novel ferrochelatase mutations in Japanese patients with erythropoietic protoporphyria: high frequency of the splice site modulator IVS3-48C polymorphism in the Japanese population.

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Hajime Nakano Research Topics

Disease

7Erythropoietic Protoporphyria
01/2022 - 12/2006
7Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa)
12/2021 - 08/2006
7Bullous Pemphigoid (Pemphigoid)
05/2021 - 12/2004
7Skin Diseases (Skin Disease)
05/2017 - 02/2007
5Psoriasis (Pustulosis Palmaris et Plantaris)
04/2016 - 02/2007
4Benign Familial Pemphigus (Hailey Hailey Disease)
06/2022 - 03/2014
4Inflammation (Inflammations)
12/2021 - 07/2008
4Epidermolysis Bullosa Pruriginosa
11/2016 - 08/2012
4Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
10/2009 - 10/2004
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2022 - 06/2017
3Darier Disease (Darier's Disease)
01/2022 - 01/2017
3Acrodermatitis enteropathica
12/2021 - 06/2003
3Dermatitis
08/2021 - 01/2006
3Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
08/2018 - 04/2013
3Neoplasms (Cancer)
09/2015 - 10/2005
3Contact Dermatitis (Eczema, Contact)
03/2014 - 03/2011
3Left Ventricular Dysfunction
08/2011 - 03/2007
3Cardiovascular Diseases (Cardiovascular Disease)
02/2005 - 10/2004
2Acantholysis
01/2022 - 01/2012
2Pyoderma Gangrenosum
01/2022 - 03/2019
2Exanthema (Rash)
09/2021 - 05/2017
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2021 - 05/2017
2Erythema
05/2021 - 10/2005
2Blister (Bulla)
01/2021 - 01/2006
2Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
05/2020 - 11/2013
2Incontinentia Pigmenti (Bloch Sulzberger Syndrome)
10/2019 - 08/2017
2Fibrosis (Cirrhosis)
10/2017 - 10/2009
2Alopecia (Baldness)
05/2017 - 05/2015
2Heart Failure
08/2011 - 04/2009
1COVID-19
06/2022
1Hypersensitivity (Allergy)
06/2022
1Symptom Flare Up
06/2022
1Drug Eruptions (Drug Eruption)
06/2022
1Acute Generalized Exanthematous Pustulosis
01/2022
1Headache (Headaches)
12/2021
1Lichen Planus (Lichen Ruber Planus)
09/2021
1Rhabdomyolysis
08/2021
1Contracture
05/2021
1Wounds and Injuries (Trauma)
01/2021
1Kyrle disease
12/2020
1Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency)
11/2020
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
10/2018
1Piebaldism (Partial Albinism)
07/2018
1Bites and Stings (Sting)
04/2018
1Infections
04/2018

Drug/Important Bio-Agent (IBA)

8Collagen Type VIIIBA
12/2021 - 08/2006
7Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2004
6Ferrochelatase (Heme Synthetase)IBA
01/2022 - 12/2006
5AutoantibodiesIBA
05/2021 - 04/2015
5AntigensIBA
05/2020 - 12/2004
4Messenger RNA (mRNA)IBA
06/2022 - 11/2014
4Cyclosporine (Ciclosporin)FDA LinkGeneric
12/2021 - 07/2008
4Keratin-5 (Keratin 5)IBA
08/2018 - 01/2012
43-Iodobenzylguanidine (Iobenguane)IBA
04/2009 - 10/2004
3Adrenal Cortex Hormones (Corticosteroids)IBA
12/2021 - 10/2019
3protoporphyrin IXIBA
06/2019 - 06/2017
2Protein Isoforms (Isoforms)IBA
01/2022 - 01/2017
2Nonsense Codon (Nonsense Mutation)IBA
12/2021 - 03/2021
2AntibodiesIBA
01/2021 - 01/2015
2Keratins (Keratin)IBA
12/2020 - 06/2008
2EnzymesIBA
06/2019 - 05/2016
2Methotrexate (Mexate)FDA LinkGeneric
10/2018 - 10/2017
2InterferonsIBA
04/2018 - 02/2007
2Aminolevulinic Acid (Levulan)FDA Link
10/2017 - 01/2005
2Immunoglobulin A (IgA)IBA
05/2015 - 03/2010
2Glycine (Aminoacetic Acid)FDA LinkGeneric
08/2012 - 06/2009
2Irritants (Vesicants)IBA
02/2012 - 03/2011
2ZincIBA
02/2012 - 06/2003
2CytokinesIBA
07/2011 - 02/2007
21-phenyl-3,3-dimethyltriazene (PDT)IBA
10/2005 - 01/2005
1COVID-19 VaccinesIBA
06/2022
1Pharmaceutical PreparationsIBA
06/2022
1VaccinesIBA
06/2022
1Adenosine Triphosphatases (ATPase)IBA
06/2022
1GemcitabineFDA Link
01/2022
1betamethasone-17,21-dipropionate (betamethasone dipropionate)FDA LinkGeneric
01/2022
1Clarithromycin (Biaxin)FDA LinkGeneric
01/2022
1calcipotriene (calcipotriol)FDA LinkGeneric
01/2022
1Ointments (Pastes)IBA
01/2022
1Calcium-Transporting ATPases (Ca2+ ATPase)IBA
01/2022
1apremilastIBA
12/2021
1Anti-Bacterial Agents (Antibiotics)IBA
12/2021
1Carboplatin (JM8)FDA LinkGeneric
09/2021
1Pemetrexed (MTA)FDA Link
09/2021
1pembrolizumabIBA
09/2021
1KeroseneIBA
08/2021
1Immunoglobulin G (IgG)IBA
01/2021
1coproporphyrinogen IIIIBA
11/2020
1Oxidoreductases (Dehydrogenase)IBA
11/2020
1Initiator Codon (Start Codon)IBA
11/2020
1Urokinase Plasminogen Activator ReceptorsIBA
05/2020
1Heme (Haem)IBA
06/2019
1Adalimumab (Humira)FDA Link
03/2019
1secukinumabIBA
03/2019
1Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA
04/2018
1Antiviral Agents (Antivirals)IBA
04/2018
1DNA (Deoxyribonucleic Acid)IBA
04/2018

Therapy/Procedure

6Therapeutics
09/2021 - 10/2004
2Photochemotherapy (Photodynamic Therapy)
10/2005 - 01/2005
1Blood Component Removal (Apheresis)
05/2021